SIMPLEX OPTIMIZATION FOR THE SPECTROPHOTOMETRIC DETERMINATION OF AZITHROMYCIN DRUG VIA ION-PAIR FORMATION

Authors

  • Ali Khalil Mahmood Department of Chemistry, College of Education for Pure Sciences/ Ibn Al-Haitham, University of Baghdad, Baghdad, IRAQ.
  • Hasan Mohammed Luaibi Department of Renewable Energy, College of Energy and environment Sciences, Alkarkh University of Science, IRAQ.
  • Khalid Waleed S. Al-Janabi Department of Chemistry, College of Education for Pure Sciences/ Ibn Al-Haitham, University of Baghdad, Baghdad, IRAQ.
  • Tayser Sumer Gaaz Prosthetics and Orthotics Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Babylon, 51001, IRAQ. https://orcid.org/0000-0003-2352-7879

DOI:

https://doi.org/10.22452/mjs.vol43no2.7

Abstract

A spectrophotometric determination of azithromycin was optimized using the simplex model. The approach has been proven to be accurate and sensitive. The analyte has been reacted with bromothymol blue (BTB) to form a colored ion pair which has been extracted in chloroform in a buffer medium of pH=4 of potassium phthalate. The extracted colored product was assayed at 415 nm and exhibited a linear quantification range over (1 - 20) g/ml. The excipients did not exhibit any interferences with the proposed approach for assaying azithromycin in pharmaceutical formulations.

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Published

30-06-2024

How to Cite

Ali Khalil Mahmood, Hasan Mohammed Luaibi, Khalid Waleed S. Al-Janabi, & Sumer Gaaz, T. (2024). SIMPLEX OPTIMIZATION FOR THE SPECTROPHOTOMETRIC DETERMINATION OF AZITHROMYCIN DRUG VIA ION-PAIR FORMATION. Malaysian Journal of Science (MJS), 43(2), 58–63. https://doi.org/10.22452/mjs.vol43no2.7

Issue

Vol 43 No 2 (2024): June 2024

Section

Original Articles

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