Hypoglycemic, Insulinotrophic and Cytotoxic Activity of three species of Ganoderma
Abstract
The crude extracts of Ganoderma lucidum, Ganoderma tropicum and Ganoderma tsugae were studied for insulinotrophic and hypoglycemic activities using rat pancreatic β-cell lines, BRIN-BD11 cells and normal Wistar rats. In an oral glucose tolerance test (OGTT), oral administration of 1 g/kg body weight of the crude extract resulted in a significant reduction in blood glucose in the normal rats. In acute 30 min insulin secretion tests, 1 mg/ml crude extract of all tested Ganoderma evoked a 1 - 4 fold stimulation of insulin secretion from the pancreatic β-cell lines. Of these, G. lucidum showed the highest insulinotrophic activity. In addition, cytotoxicity assay of extracts from G. lucidum, G. tropicum and G. tsugae towards rat pancreatic β-celliines showed half maximal inhibition (IC₅₀) at 200, 100 and 150µg/ml, respectively. These results demonstrated the presence of insulin-releasing and hypoglycemic activity in the crude extracts of G. lucidum, G. tropicum and G. tsugae.
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